Table 4. In Vitro Antiplasmodium Activity, Solubility, and Cytotoxicity Data of the Disubstituted Western Substituent.

^aMean from n values of ≥2 independent experiments with multidrug-resistant (K1) and sensitive (NF54) strains of P. falciparum.

^bAqueous solubility using HPLC-DAD-MS.

^cCHO = Chinese hamster ovarian cell line.

^dSelectivity index (SI) = [IC₅₀ (CHO)/IC₅₀ (PfNF54)]. ND = not determined.