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. 2020 Mar 17;5(12):6967–6982. doi: 10.1021/acsomega.0c00327

Table 7. hERG Inhibition and Microsomal Stability Data of the Active Compounds.

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a

Mean from n values of ≥2 independent experiments with multidrug-resistant (K1) and sensitive (NF54) strains of P. falciparum.

b

hERG determined at Novartis Institute for Tropical Diseases (NITD).

c

Human, mouse, and rat liver microsomes.

d

Obtained from NOVARTIS screening library and Pf activity determined at NITD. ND = not determined.