Table 8. Pharmacokinetic Parameters for Compound 3 Following Intravenous Dosing at 1 mg/kg and Oral Dosing at 5 mg/kg in Ratsa.
| intravenous
PK parameters |
oral
PK parameters |
|||||
|---|---|---|---|---|---|---|
| Vss (L/kg) | CL (mL/(min kg)) | T1/2 (h) | Cmax (μM) | Tmax (h) | AUC (μM h) | F (%) |
| 17.69 | 144 | 1.98 | 0.80 | 0.08 | 1.5 | 42 |
a
Vss = volume of distribution at steady state; CL = total systemic clearance; T1/2 = half-life, Cmax = maximum concentration of drug in plasma; Tmax = time to maximum concentration of drug in plasma; AUC = area under the curve; F = oral bioavailability; compounds were formulated in 30% N-methyl pyrrolidone/70% poly(ethylene glycol) (PEG)200 for intravenous administration and 0.5% methyl cellulose/0.5% Tween 80 in water for oral administration.