Table 4.
Differences in cognition between users and nonusers with available hsCRP data (n = 45,395)
| Number | Unique design score |
||
|---|---|---|---|
| model 1 | model 2 | ||
| Nonusers | 40,695 | Ref. | Ref. |
| Overall users | 4,700 | −1.12 (–1.76 to −0.48)*** | −1.07 (–1.71 to −0.43)** |
| Route | |||
| Local | 4,497 | −0.94 (–1.59 to −0.28)** | −0.89 (–1.55 to −0.24)** |
| Systemic | 203 | −5.18 (–8.10 to −2.25)*** | −5.04 (–7.97 to −2.12)*** |
| Single type | |||
| Systemic | 153 | −5.27 (–8.64 to −1.90)** | −5.13 (–8.50 to −1.76)** |
| Inhaled | 1,783 | −2.33 (–3.34 to −1.32)*** | −2.28 (–3.29 to −1.27)*** |
| Nasal | 1,078 | −0.37 (–1.65 to 0.92) | −0.33 (–1.61 to 0.96) |
| Dermal | 856 | 0.99 (–0.45 to 2.42) | 1.00 (–0.44 to 2.44) |
| Others | 120 | 2.37 (–1.43 to 6.17) | 2.39 (–1.41 to 6.19) |
**
p > 0.010
***
p > 0.001.
Adjusted mean differences (95% CI) in total unique design score between corticosteroids users and nonusers (reference). Model 1 is adjusted for age, sex, educational attainment, body mass index, smoking, alcohol use, physical activity, cardiovascular diseases, and use of psychotropic drugs. Model 2 is additionally adjusted for hsCRP.