Table 9.2.

BEVs produced biomolecules as diagnostic agents

Targeted/used for	Expressed product	Used to detect	Test type
Rodents	Recombinant nucleocapsid protein	Sendai virus	ELISA
Swine	G-protein	Nipah virus (NiV)	ELISA
Swine	SVDV-VLP	Swine vesicular diseases virus (SVDV)	ELISA
Horse	EIAV-core gag and p26 protein	Equine infectious anaemia virus (EIAV)	ELISA and agar gel immunodiffusion (AGID)
Horse	HA	Equine influenza strain LP/93	ELISA
Cattles	VP7	Bluetongue (BTV) and epizootic haemorrhagic disease (EHDV)	Antigen capture competitive ELISA (Ag Cap c-ELISA)
Pigs and goats	VP1 capsid protein and 3C protease	Foot-and-mouth disease virus (FMDV)-type A	Blocking ELISA
Bovine	Recombinant-F protein	Bovine respiratory syncytial virus (BRSV)	Immunofluorescence
Ducks	E protein	Tembusu virus (TMUV)	E-ELISA
Birds	APMV2-HN	Avian paramyxovirus type 2	Haemagglutination inhibition (HI) test
Geese	VP1	Goose haemorrhagic polyomavirus (GHPV)	ELISA and haemagglutinin inhibition test
Humans	Nucleocapsid protein (N)	Lassa virus	ELISA
Humans	E1, E2 and polyprotein precursor	Rubella virus (RV)	Enzyme immunoassay (EIA) and immunoblot
Humans	Flagellar repetitive antigen (FRA)	Trypanosoma cruzi	ELISA
Humans	Glutamic acid decarboxylase (GAD65 and GAD67)	Insulin-dependent diabetes mellitus	Immunoassay
Humans	Nucleocapsid protein of strain SR-11	Hantavirus	Indirect immunofluorescence antibody (IFA)
Humans	E2 protein	Human papillomavirus (HPV)	ELISA
Humans	Hou/90 capsid	Human calicivirus (HuCV)	Immunoprecipitation and EIA
Humans	Fragment of gG comprising residues 321–580 of HSV-2	Herpes simplex virus (HSV)	Indirect ELISA
Humans	Capsid proteins	Human caliciviruses (HuCVs)	EIA
Humans	C-terminus truncated form of protein (Etr)	TBE complex virus	ELISA and immunoblot assay
Humans	Recombinant Fel dl (rFel dl Ch1 + Ch2)	Cat allergen	Radioimmunoassay (RIA) and ELISA
Humans	Recombinant human tissue TG (hu-tTG)	Autoantigen transglutaminase (TG)	ELISA
Humans	Envelop glycoproteins gB, gD, gC, gE and gG	Herpes B virus (HBV)	ELISA