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Effects of miR-665 on cell proliferation of H1299 and A549 cells. Expression of miR-665 was significantly increased by the miR-665 mimic, but was suppressed by the miR-665 inhibitor in (A) H1299 and (B) A549 cells. Overexpression of miR-665 in (C) H1299 and (D) A549 cells resulted in increased cell proliferation, whereas the knockdown of miR-665 led to inhibited cell proliferation. *P<0.05, **P<0.01, ***P<0.001 vs. Mock. NC, negative control; miR-665, miRNA-665; OD, optical density.
