Table II.

Identification of the significantly altered metabolites in HGC-27 cells.

Metabolite	Formula	M/Z	P-value	Regulation	VIP
SM (d18:+B5:G321/14:0)	C37H75N2O6P	719,5313	8.951×10−6	Downregulated	1,5850
SM [d18:0/16:1(9Z)]	C39H79N2O6P	747,5634	2.004×10−2	Downregulated	1,8047
PS [DiMe(11,3)/MonoMe(11,5)]	C47H80NO12P	918,4877	1.500×10−8	Downregulated	1,1943
PS [18:3(9Z,12Z,15Z)/22:1(13Z)]	C46H82NO10P	822,5620	9.948×10−3	Downregulated	1,2988
PS [14:1(9Z)/24:0]	C44H84NO10P	800,5760	1.440×10−7	Downregulated	3,0884
PE-NMe2 [14:1(9Z)/16:1(9Z)]	C37H70NO8P	732,4793	2.400×10−8	Downregulated	3,9878
PE-NMe [14:1(9Z)/16:1(9Z)]	C36H68NO8P	718,4649	4.190×10−6	Downregulated	1,0028
PE (15:0/P-16:0)	C36H72NO7P	706,4990	1.223×10−6	Upregulated	1,8137
PE [15:0/24:1(15Z)]	C44H86NO8P	832,6037	4.555×10−3	Upregulated	1,3361
PE [15:0/22:5(4Z,7Z,10Z,13Z,16Z)]	C42H74NO8P	796,5100	7.155×10−4	Upregulated	1,4220
PE [15:0/22:4(7Z,10Z,13Z,16Z)]	C42H76NO8P	798,5255	2.232×10−2	Upregulated	1,3835
PE [15:0/22:2(13Z,16Z)]	C42H80NO8P	802,5564	1.816×10−2	Downregulated	2,8050
PE [15:0/22:1(13Z)]	C42H82NO8P	804,5728	7.846×10−5	Upregulated	4,1810
PE [15:0/20:2(11Z,14Z)]	C40H76NO8P	774,5259	9.433×10−6	Downregulated	8,3376
PE [15:0/18:2(9Z,12Z)]	C38H72NO8P	746,4948	1.153×10−6	Downregulated	4,9712
PE [14:0/24:1(15Z)]	C43H84NO8P	818,5870	9.771×10−6	Upregulated	1,1963
PE [14:0/20:2(11Z,14Z)]	C39H74NO8P	757,5542	4.356×10−3	Downregulated	2,1212
PC [o-16:0/20:4(8Z,11Z,14Z,17Z)]	C44H82NO7P	812,5771	1.832×10−2	Upregulated	1,2528
PC [22:5(4Z,7Z,10Z,13Z,16Z)/16:0]	C46H82NO8P	852,5716	4.918×10−2	Upregulated	2,0817
PC [22:4(7Z,10Z,13Z,16Z)/14:0]	C44H80NO8P	826,5566	7.767×10−6	Upregulated	3,9909
PC [18:4(6Z,9Z,12Z,15Z)/P-18:0]	C44H80NO7P	810,5616	3.320×10−7	Upregulated	2,0711
PC [18:4(6Z,9Z,12Z,15Z)/P-16:0]	C42H76NO7P	782,5270	1.608×10−5	Upregulated	1,0437
PC [18:1(11Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z)]	C48H82NO8P	876,5722	2.134×10−4	Upregulated	1,7139
PC [18:0/20:4(5Z,8Z,11Z,14Z)]	C46H84NO8P	854,5879	9.655×10−6	Upregulated	1,5839
PC [18:0/18:2(9Z,12Z)]	C44H84NO8P	830,5881	6.867×10−4	Upregulated	2,3650
PC [16:1(9Z)/20:3(5Z,8Z,11Z)]	C44H80NO8P	826,5554	1.198×10−4	Upregulated	1,5843
PC [16:1(9Z)/16:1(9Z)]	C40H76NO8P	752,5196	2.971×10−2	Downregulated	4,8632
PC [16:0/20:5(5Z,8Z,11Z,14Z,17Z)]	C44H78NO8P	824,5400	9.291×10−3	Upregulated	3,4401
PC [16:0/20:3(5Z,8Z,11Z)]	C44H82NO8P	826,5554	6.358×10−3	Upregulated	1,4770
PC (16:0/18:3(6Z,9Z,12Z)]	C42H78NO8P	800,5412	9.244×10−4	Upregulated	2,2188
PA (16:0/18:1(11Z)]	C37H71O8P	719,4839	4.759×10−6	Downregulated	1,2779
LysoPC [20:4(8Z,11Z,14Z,17Z)]	C28H50NO7P	588,3274	5.778×10−5	Upregulated	1,7989
Sphinganine	C18H39NO2	302,3052	6.998×10−3	Upregulated	2,7342
Oleamide	C18H35NO	563,5495	7.274×10−4	Upregulated	31,6443
Linoleamide	C18H33NO	280,2632	1.702×10−2	Upregulated	10,9674
Lactosylceramide (d18:1/12:0)	C42H79NO13	850,5563	5.000×10−9	Upregulated	3,5254
Glycerophosphocholine	C8H20NO6P	258,1098	1.328×10−2	Upregulated	1,5225
Dihydroceramide	C19H39NO3	362,3264	2.622×10−2	Upregulated	1,9767

VIP, variable importance; M/Z, mass-to-charge ratio; SM, sphingomyelin; PS, phosphatidylserine; PE, phosphatidylethanolamine; PC, phosphatidylcholine; PA, phosphatidic acid; LysoPC, lysophosphatidylcholine.