Skip to main content
. 2020 Mar 19;23(4):100990. doi: 10.1016/j.isci.2020.100990

Figure 8.

Figure 8

Influences on PCK-2 Expression by Perturbing Mitochondrial Functions

(A) Cartoon of the mitochondrial electron transport system, and site of action for mutations and electron transport chain toxins.

(B–G) (B) Yellow emission fluorescence intensity of PCK-2::YFP in L4 and day 1 (D1) through day 3 (D3) hermaphrodites grown in the absence (−) or presence (+) of rotenone (B), azide (C), oligomycin (D), and malonate (G) or containing mutations in mev-1(kn1) (E) and sdha-1(rg550) (F and G). Yellow emission fluorescence intensity of day 1 (D1) and day 3 (D3) wild-type or sdha-1(rg550) PCK-2::YFP hermaphrodites grown in the absence (−) or presence (+) of malonate. Bars and whiskers represent mean and standard deviation. (B–G) Numbers above the bars represent percent increase or decrease (−) between treated or mutant animals relative to the untreated or wild-type reference. p values were determined using the Mann-Whitney test; ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001, ∗∗∗∗p < 0.0001. Numbers of animals quantified are listed at the bottom of the graphs.