Table 1.

Pathways and processes associated with differentially expressed proteins in response to BTZ and CFZ treatments.

Pathway/process	p-value
Response to BTZ following 3 h
Cell Cycle Checkpoints	0,002
Ribosome - Homo sapiens (human)	0,011
Post-translational protein modification	0,012
Cell Cycle, Mitotic	0,013
Ub-specific processing proteases	0,023
Response to BTZ following 24 h
Cellular response to heat stress	4,20 × 10-7
HSF1-dependent transactivation	7,06 × 10-7
HSP90 chaperone cycle for steroid hormone receptors (SHR)	1,73 × 10-6
Regulation of HSF1-mediated heat shock response	2,26 × 10-6
HSF1 activation	1,34 × 10-5
PINK1/Parkin Mediated Mitophagy	0,005
Mitophagy	0,009
Response to CFZ following 3 h
mitochondrial fatty acid beta-oxidation of saturated fatty acids	4,93 × 10-5
The citric acid (TCA) cycle and respiratory electron transport	1,81 × 10-4
Fatty acid degradation - Homo sapiens (human)	2,27 × 10-4
Citric acid cycle (TCA cycle)	4,35 × 10-4
Mitochondrial calcium ion transport	0,008
Calcium signaling pathway - Homo sapiens (human)	0,009
Fatty acid metabolism	0,009
mRNA Splicing	0,009
Glycogen metabolism	0,010
PINK1/Parkin Mediated Mitophagy	0,010
Mitophagy	0,018
Apoptotic execution phase	0,049
Response to CFZ following 24 h
Cellular response to heat stress	4,20 × 10-7
HSF1-dependent transactivation	7,06 × 10-7
HSP90 chaperone cycle for steroid hormone receptors (SHR)	1,73 × 10-6
Regulation of HSF1-mediated heat shock response	2,26 × 10-6
HSF1 activation	1,34 × 10-5
Degradation of GLI2 by the proteasome	0,002
Degradation of GLI1 by the proteasome	0,002
PINK1/Parkin Mediated Mitophagy	0,005
Mitophagy	0,009
Apoptotic execution phase	0,025
Cell Cycle, Mitotic	0,026