Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Mar 3;21(5):2171–2181. doi: 10.3892/mmr.2020.11010

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright: © Lin et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

PMC Copyright notice

Figure 1. — Nec-1 protects against LPS-induced inflammatory response and lung injury in a mouse model of ALI. (A) Histopathological analysis of the effects of Nec-1 on LPS-induced experimental ALI using hematoxylin and eosin staining (magnification, ×100 and ×200). The black arrow indicates areas of lung injury. (B) Effects of Nec-1 on LPS-induced experimental ALI were assessed by estimating the levels of total secretory proteins using a bicinchoninic acid kit. (C and D) Levels of secreted inflammatory cytokines isolated from (C) BALF and (D) lung tissues were estimated by ELISA, in order to assess the effects of Nec-1 on LPS-induced ALI. Data are shown as the mean ± SEM from at least three independent experiments (n=5 mice/group). *P<0.05, as indicated. ALI, acute lung injury; BALF, bronchoalveolar lavage fluid; IL, interleukin; LPS, lipopolysaccharide; Nec-1, necrostatin-1; TNF-α, tumor necrosis factor-α.