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. 2020 Mar 3;21(5):2171–2181. doi: 10.3892/mmr.2020.11010

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Copyright: © Lin et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 6. — Schematic diagram of Nec-1-mediated protection from ALI-associated inflammatory injuries. Nec-1 triggered anti-ROS production by inhibiting necroptosis. Nec-1 also alleviated ALI symptoms, such as alveolar cell death, alveolar wall disorder, lung edema and the expression of inflammatory cytokines by directly suppressing necroptosis. HO-1, heme oxygenase-1; Nec-1, necrostatin-1; NRF2, nuclear factor erythroid 2-related factor 2; ROS, reactive oxygen species; SOD2, superoxide dismutase 2.