Table II.
Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis for the 491 overlapping genes between differentially expressed genes and differentially methylated genes.
| Term | Count | P-value | Genes |
|---|---|---|---|
| hsa04010: MAPK signaling pathway | 8 | 4.903×10−3 | MAP3K7, RPS6KA5, RPS6KA6, MKNK2, PLA2G1B, FGF13, PRKACB, GADD45A |
| hsa05200: Pathways in cancer | 9 | 5.179×10−3 | LAMA1, CDKN1A, CTBP1, HSP90B1, ERBB2, PML, FGF13, FZD3, ZBTB16 |
| hsa00230: Purine metabolism | 5 | 1.256×10−2 | POLR2J, PNPT1, PDE5A, PDE4D, POLR2D |
| hsa04621: NOD-like receptor signaling pathway | 3 | 1.831×10−2 | MAP3K7, HSP90B1, TNFAIP3 |
| hsa04115: p53 signaling pathway | 3 | 2.107×10−2 | CDKN1A, GADD45A, TP73 |
| hsa04120: Ubiquitin mediated proteolysis | 4 | 2.477×10−2 | PRPF19, UBE2D4, UBE2A, PML |
| hsa04520: Adherens junction | 3 | 2.527×10−2 | MAP3K7, PTPRM, ERBB2 |
| hsa04310: Wnt signaling pathway | 4 | 2.958×10−2 | MAP3K7, CTBP1, FZD3, PRKACB |
| hsa04540: Gap junction | 3 | 3.090×10−2 | TUBA8, TUBA4A, PRKACB |
| hsa04020: Calcium signaling pathway | 4 | 3.827×10−2 | ERBB2, PRKACB, MYLK, F2R |
| hsa04510: Focal adhesion | 4 | 4.673×1°−2 | LAMA1, ERBB2, MYLK, SPP1 |