Table III.
The GO functional annotations in terms of biology process, molecular function, and cellular component for the genes in the protein-protein interaction network.
| Category | Term | Count | P-value | Genes |
|---|---|---|---|---|
| Biology process | GO:0033554~cellular response to stress | 16 | 4.190×10−5 | HMGB2, UBE2A, DERL1, GEN1, PML, RAD9A, SIRT7, TP73, TRIB1, SCAP, PRPF19, CDKN1A, MRPS9, FANCD2, SUPT16H, GADD45A |
| GO:0009890~negative regulation of biosynthetic process | 15 | 1.820×10−4 | CTBP1, HMGB2, CDX4, HDAC10, PML, ZNF24, RAD9A, SNW1, SIRT7, DMAP1, ZBTB16, SCAP, HHEX, HDAC3, IGFBP5 | |
| GO:0042127~regulation of cell proliferation | 16 | 1.434×10−3 | B4GALT1, RBP4, CTBP1, UBE2A, ERBB2, PML, ZBTB16, SSR1, TRIB1, S1PR3, HHEX, CDKN1A, ZMIZ1, IL12B, F2R, IGFBP5 | |
| GO:0042981~regulation of apoptosis | 16 | 1.770×10−3 | B4GALT1, ERBB2, PML, RAD9A, ZBTB16, TP73, MAP3K7, HDAC3, CDKN1A, HSP90B1, GSPT1, BNIP1, POU4F1, IL12B, TNFAIP3, F2R | |
| GO:0043067~regulation of programmed cell death | 16 | 1.950×10−3 | B4GALT1, ERBB2, PML, RAD9A, ZBTB16, TP73, MAP3K7, HDAC3, CDKN1A, HSP90B1, GSPT1, BNIP1, POU4F1, IL12B, TNFAIP3, F2R | |
| GO:0010941~regulation of cell death | 16 | 2.021×10−3 | B4GALT1, ERBB2, PML, RAD9A, ZBTB16, TP73, MAP3K7, HDAC3, CDKN1A, HSP90B1, GSPT1, BNIP1, POU4F1, IL12B, TNFAIP3, F2R | |
| GO:0007049~cell cycle | 15 | 3.435×10−3 | PML, SIRT7, BOLL, TP73, KIF2C, HHEX, HDAC3, CDKN1A, NUMA1, GSPT1, NCAPG2, FANCD2, SKA3, IL12B, GADD45A | |
| GO:0007242~intracellular signaling cascade | 19 | 1.030×10−2 | HMGB2, TLR10, ERBB2, MKNK2, PML, FGF13, RAD9A, TP73, TRIB1, LEP, MAP3K7, RPS6KA5, S1PR3, RPS6KA6, RNF4, ARL8B, PRKACB, F2R, IGFBP5 | |
| Cellular component | GO:0031974~membrane-enclosed lumen | 34 | 1.500×10−7 | PDP1, HMGB2, PNMA2, POLR2J, PNPT1, PML, ZBTB16, DMAP1, POLR2D, PRPF19, ALAS1, NUMA1, POU3F1, ETFB, PDCD11, CTBP1, ZMYM3, HDAC10, RAD9A, SNW1, SIRT7, ELL3, RPS6KA5, NVL, HSP90B1, CDKN1A, HDAC3, MRPS9, FANCD2, ZMIZ1, SUPT16H, MATR3, EP400, PNMA1 |
| GO:0070013~intracellular organelle lumen | 33 | 1.950×10−7 | PDP1, HMGB2, PNMA2, POLR2J, PML, ZBTB16, DMAP1, POLR2D, PRPF19, ALAS1, NUMA1, POU3F1, ETFB, PDCD11, CTBP1, ZMYM3, HDAC10, RAD9A, SNW1, SIRT7, ELL3, RPS6KA5, NVL, HSP90B1, CDKN1A, HDAC3, MRPS9, FANCD2, ZMIZ1, SUPT16H, MATR3, EP400, PNMA1 | |
| GO:0043233~organelle lumen | 33 | 3.300×10−7 | PDP1, HMGB2, PNMA2, POLR2J, PML, ZBTB16, DMAP1, POLR2D, PRPF19, ALAS1, NUMA1, POU3F1, ETFB, PDCD11, CTBP1, ZMYM3, HDAC10, RAD9A, SNW1, SIRT7, ELL3, RPS6KA5, NVL, HSP90B1, CDKN1A, HDAC3, MRPS9, FANCD2, ZMIZ1, SUPT16H, MATR3, EP400, PNMA1 | |
| GO:0031981~nuclear lumen | 28 | 1.320×10−6 | HMGB2, PNMA2, POLR2J, PML, ZBTB16, DMAP1, POLR2D, PRPF19, NUMA1, POU3F1, CTBP1, PDCD11, ZMYM3, HDAC10, RAD9A, SNW1, SIRT7, ELL3, NVL, RPS6KA5, CDKN1A, HDAC3, FANCD2, ZMIZ1, SUPT16H, MATR3, EP400, PNMA1 | |
| GO:0005654~nucleoplasm | 19 | 3.520×10−5 | HMGB2, CTBP1, POLR2J, HDAC10, PML, DMAP1, ZBTB16, ELL3, POLR2D, RPS6KA5, PRPF19, HDAC3, NUMA1, CDKN1A, FANCD2, ZMIZ1, SUPT16H, POU3F1, EP400 | |
| GO:0043232~intracellular non-membrane-bounded organelle | 36 | 3.790×10−5 | HMGB2, PNMA2, USP2, PML, ZBTB16, DMAP1, KIF2C, NUMA1, SKA3, TRIP10, CNKSR2, PDCD11, UBE2A, ZMYM3, RNF19A, PDE4D, RAD9A, SNW1, SIRT7, PALLD, TNKS1BP1, NVL, HDAC3, TUBA8, MRPS9, FANCD2, RPS4Y2, TPPP, SUPT16H, TUBA4A, OPHN1, ARL8B, TNFAIP3, EP400, LCP1, PNMA1 | |
| GO:0043228~non-membrane-bounded organelle | 36 | 3.790×10−5 | HMGB2, PNMA2, USP2, PML, ZBTB16, DMAP1, KIF2C, NUMA1, SKA3, TRIP10, CNKSR2, PDCD11, UBE2A, ZMYM3, RNF19A, PDE4D, RAD9A, SNW1, SIRT7, PALLD, TNKS1BP1, NVL, HDAC3, TUBA8, MRPS9, FANCD2, RPS4Y2, TPPP, SUPT16H, TUBA4A, OPHN1, ARL8B, TNFAIP3, EP400, LCP1, PNMA1 | |
| GO:0044430~cytoskeletal part | 15 | 6.493×10−3 | CNKSR2, USP2, RNF19A, PDE4D, PALLD, KIF2C, NUMA1, HDAC3, TUBA8, TPPP, TUBA4A, SKA3, ARL8B, TNFAIP3, LCP1 | |
| GO:0005856~cytoskeleton | 17 | 3.066×10−2 | CNKSR2, USP2, RNF19A, PDE4D, PALLD, KIF2C, TUBA8, NUMA1, HDAC3, TPPP, TUBA4A, OPHN1, SKA3, ARL8B, TNFAIP3, TRIP10, LCP1 | |
| Molecular function | GO:0000166~nucleotide binding | 31 | 2.349×10−3 | ERBB2, MKNK2, HELZ, POLR2D, TRIB1, MAP3K7, UBE2D4, KIF2C, ADCK1, ACAD8, PRKACB, UBE2A, CTBP1, SIRT7, ALK, ABCB6, BOLL, ATAD1, RPS6KA5, NVL, RPS6KA6, TUBA8, HSP90B1, GSPT1, PDE5A, TUBA4A, ARL8B, MATR3, MYLK, EP400, ATAD2B |
| GO:0001883~purine nucleoside binding | 23 | 7.436×10−3 | UBE2A, ERBB2, MKNK2, HELZ, ALK, ABCB6, ATAD1, TRIB1, RPS6KA5, NVL, MAP3K7, UBE2D4, RPS6KA6, KIF2C, HSP90B1, ADCK1, PDE5A, ACAD8, ARL8B, PRKACB, MYLK, EP400, ATAD2B | |
| GO:0001882~nucleoside binding | 23 | 8.046×10−3 | UBE2A, ERBB2, MKNK2, HELZ, ALK, ABCB6, ATAD1, TRIB1, RPS6KA5, NVL, MAP3K7, UBE2D4, RPS6KA6, KIF2C, HSP90B1, ADCK1, PDE5A, ACAD8, ARL8B, PRKACB, MYLK, EP400, ATAD2B | |
| GO:0017076~purine nucleotide binding | 26 | 8.216×10−3 | ERBB2, MKNK2, HELZ, TRIB1, MAP3K7, KIF2C, UBE2D4, ADCK1, ACAD8, PRKACB, UBE2A, ALK, ABCB6, ATAD1, NVL, RPS6KA5, RPS6KA6, HSP90B1, TUBA8, GSPT1, PDE5A, TUBA4A, ARL8B, EP400, MYLK, ATAD2B | |
| GO:0032555~purine ribonucleotide binding | 25 | 9.376×10−3 | UBE2A, ERBB2, MKNK2, HELZ, ALK, ABCB6, ATAD1, TRIB1, RPS6KA5, NVL, MAP3K7, UBE2D4, RPS6KA6, KIF2C, TUBA8, HSP90B1, ADCK1, GSPT1, PDE5A, TUBA4A, ARL8B, PRKACB, MYLK, EP400, ATAD2B | |
| GO:0032553~ribonucleotide binding | 25 | 9.376×10−3 | UBE2A, ERBB2, MKNK2, HELZ, ALK, ABCB6, ATAD1, TRIB1, RPS6KA5, NVL, MAP3K7, UBE2D4, RPS6KA6, KIF2C, TUBA8, HSP90B1, ADCK1, GSPT1, PDE5A, TUBA4A, ARL8B, PRKACB, MYLK, EP400, ATAD2B | |
| GO:0030554~adenyl nucleotide binding | 21 | 2.425×10−2 | UBE2A, ERBB2, MKNK2, HELZ, ALK, ABCB6, ATAD1, TRIB1, RPS6KA5, NVL, MAP3K7, UBE2D4, RPS6KA6, KIF2C, ADCK1, HSP90B1, ACAD8, PRKACB, MYLK, EP400, ATAD2B | |
| GO:0005524~ATP binding | 20 | 2.459×10−2 | UBE2A, ERBB2, MKNK2, HELZ, ALK, ABCB6, ATAD1, TRIB1, RPS6KA5, NVL, MAP3K7, UBE2D4, RPS6KA6, KIF2C, ADCK1, HSP90B1, PRKACB, MYLK, EP400, ATAD2B | |
| GO:0032559~adenyl ribonucleotide binding binding | 20 | 2.782×10−2 | UBE2A, ERBB2, MKNK2, HELZ, ALK, ABCB6, ATAD1, TRIB1, RPS6KA5, NVL, MAP3K7, UBE2D4, RPS6KA6, KIF2C, ADCK1, HSP90B1, PRKACB, MYLK, EP400, ATAD2B |
GO, Gene Ontology.