Table 2.
Proinflammatory mediators suppressed by INSs [21]
Mediator | Components/role |
---|---|
Cytokines | Includes IL-6, IL-8; synthesis of IgE antibodies |
Langerhans cells | IgE synthesis and stimulation of T cells |
Lymphocytes | Activated T cells such as CD3+, CD4+, CD8+, and CD25+ cells |
Mast cells | IgE-dependent histamine release |
Basophils | Production of IL-4 and IL-13 and release of IgE-dependent histamine |
Eosinophils | Cytokines such as IL-4 and IL-5 |