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Proinflammatory mediators suppressed by INSs [21]
| Mediator | Components/role |
|---|---|
| Cytokines | Includes IL-6, IL-8; synthesis of IgE antibodies |
| Langerhans cells | IgE synthesis and stimulation of T cells |
| Lymphocytes | Activated T cells such as CD3+, CD4+, CD8+, and CD25+ cells |
| Mast cells | IgE-dependent histamine release |
| Basophils | Production of IL-4 and IL-13 and release of IgE-dependent histamine |
| Eosinophils | Cytokines such as IL-4 and IL-5 |
