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. 2020 Mar 5;56(5):1115–1128. doi: 10.3892/ijo.2020.5005

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Copyright: © Jin et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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DJ-1 promotes EMT via the Wnt/β-catenin signaling pathway in esophageal squamous cell carcinoma. (A) LV-DJ-1 cells had a significantly higher migration and invasion ability compared with the control group (magnification, x200). (B) The adhesion ability was significantly increased in LV-DJ-1 cells. (C) DJ-1 overexpression promoted the EMT process by significantly reducing E-cadherin expression and significantly increasing the vimentin and N-cadherin expression. (D) LRP6, p-LRP6 and β-catenin expression were significantly upregulated, while Axin1 expression was significantly downregulated in LV-DJ-1 cells. The ratio of p-LRP6 to total LRP6 protein exhibited no significant change between the control group and DJ-1 overexpression group. ^*P<0.05, ^**P<0.01 vs. LV-con. LV-DJ-1, lentivirus overexpressing DJ-1; LV-con, lentivirus control; LRP-6, lipoprotein receptor-related protein 6; p-. phosphorylated.