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. 2020 Mar 4;56(5):1083–1092. doi: 10.3892/ijo.2020.5003

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Copyright: © Zhao et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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FOXF1 regulates cisplatin resistance by promoting cell proliferation and inhibiting cell apoptosis. (A) FOXF1 expression levels were increased in A549 and H1299 cells following transfection of FOXF1 plasmids and were decreased in A549/DDP cells following transfection of FOXF1 shRNAs. (B) Overexpression of FOXF1 increased resistance to cisplatin in A549 and H1299 cells (DDP treatment), and the knockdown of FOXF1 decreased resistance to cisplatin in A549/DDP cells (DDP treatment). (C) Overexpression of FOXF1 increased the colony-formation capability of A549 and H1299 cells (DDP treatment), and the knockdown of FOXF1 decreased the colony-formation capability in A549/DDP cells (DDP treatment) (clone formation rate = clones/inoculated amount of cells ×100%). (D) Overexpression of FOXF1 decreased the cisplatin-induced apoptosis of A549 and H1299 cells (DDP treatment), and the knockdown of FOXF1 increased the cisplatin-induced apoptosis of A549/DDP cells (DDP treatment). The late apoptotic cells are shown in the bar graph (n=3);^*P<0.05 (FOXF1 plasmids compared to control plasmids, FOXF1 shRNAs compared to control shRNAs). FOXF1, forkhead box F1.

FOXF1 regulates cisplatin resistance by promoting cell proliferation and inhibiting cell apoptosis. (A) FOXF1 expression levels were increased in A549 and H1299 cells following transfection of FOXF1 plasmids and were decreased in A549/DDP cells following transfection of FOXF1 shRNAs. (B) Overexpression of FOXF1 increased resistance to cisplatin in A549 and H1299 cells (DDP treatment), and the knockdown of FOXF1 decreased resistance to cisplatin in A549/DDP cells (DDP treatment). (C) Overexpression of FOXF1 increased the colony-formation capability of A549 and H1299 cells (DDP treatment), and the knockdown of FOXF1 decreased the colony-formation capability in A549/DDP cells (DDP treatment) (clone formation rate = clones/inoculated amount of cells ×100%). (D) Overexpression of FOXF1 decreased the cisplatin-induced apoptosis of A549 and H1299 cells (DDP treatment), and the knockdown of FOXF1 increased the cisplatin-induced apoptosis of A549/DDP cells (DDP treatment). The late apoptotic cells are shown in the bar graph (n=3);^*P<0.05 (FOXF1 plasmids compared to control plasmids, FOXF1 shRNAs compared to control shRNAs). FOXF1, forkhead box F1.