Table 2.

In silico modeling of the effect of MASP-2 missense substitution on the protein function

#	DNA change	Protein change	SNP ID	Domains	In silico modeling		Interspecies alignment
					Prediction	Scorea	Homo Sapiens	Rattus novergicus	Galus Galus	Xenopus tropicalis	Cyprinus Carpio
1	c.296 G > A	p. R99Q	Rs61735600	CUBI	Likely benign	0.306	R	R	E	K	D
2	c.359 A > G	p.D120G	rs72550870	CUBI	Probably damaging	2.871	D	D	D	D	D
3	c.377 C > T	p.P126L	rs56392418	CUBI	Likely benign	1.188	P	P	P	E	R
4	c.1111 G > T	p.D371Y	rs12711521	CCP2	Likely benign	1.374	D	D	D	D	E
5	c.1130 T > C	p.V377A	rs2273346	CCP2	Likely benign	1.305	V	V	I	Y	M

^aGreater scores indicate higher probability to impair the protein function; factors taken into account for the calculation of the score are as follows: difference in thermo-physical properties of the wt and mutant protein; and evolutionary preservation of the residue in the corresponding position.