Fig. 1.

Diagram of basic interactions by which the multifunctional BMV 1a protein directs assembly of the membrane-bound viral RNA replication complex, including: 1a interaction with the cytoplasmic face of the ER membrane; 1a–1a interaction; interaction of the 1a helicase-like domain with the N-terminal extension of the 2a polymerase; and 1a interaction with the cis-acting recognition element (RE) on viral genomic RNAs, leading to recruitment of viral RNA to the RNA replication compartment. See main text for further details.