Table 3.
IgG antibody titers of monkeys immunized with inactive SARS CoV candidate
Dose(μg) | Animal | Days post first immunization |
|||||||
---|---|---|---|---|---|---|---|---|---|
0 | 3 | 7 | 11 | 14 | 21 | 28 (day 8 p.i.) | 35 (day 15 p.i.) | ||
0.5 | #1 | <100 | <100 | <100 | <100 | <100 | 200 | 800 | 3200 |
#2 | <100 | <100 | 100 | <100 | <100 | <100 | 100 | 100 | |
#3 | <100 | <100 | 200 | <100 | 400 | 800 | 1600 | 3200 | |
#4 | <100 | <100 | 100 | <100 | 800 | 1600 | 3200 | 1600 | |
5 | #5 | <100 | 100 | 200 | 400 | 800 | 3200 | >12800 | >12800 |
#6 | <100 | <100 | 100 | <100 | <100 | <100 | <100 | 200 | |
#7 | <100 | <100 | 100 | 100 | 400 | 1600 | 1600 | 3200 | |
#8 | <100 | 100 | 400 | 800 | 1600 | 3200 | 6400 | 6400 | |
50 | #9 | <100 | 100 | 400 | 800 | 1600 | >6400 | >12800 | >12800 |
#10 | <100 | 100 | 200 | 400 | 400 | 1600 | 6400 | 6400 | |
#11 | <100 | <100 | 100 | 200 | 800 | >3200 | 12800 | 12800 | |
#12 | <100 | <100 | 200 | 400 | 400 | 1600 | 3200 | >12800 | |
PBS | #15 | <100 | <100 | <100 | <100 | <100 | <100 | NTa | NTa |
#16 | <100 | <100 | <100 | <100 | <100 | <100 | NTa | NTa |
Titers are reported as the inverse of the last dilution of serum for which the OD value is greater than 0.1 absorbance units and at least 2.1-fold that of the control.
NT: not test.