Table 2.
Individual scores for each characteristic evaluated and overall process scores for each pathogen according to a conventional egg-based, vaccine-manufacturing scenario (egg > egg)
| Virus group | Virus family | Type/species | Individual score for each characteristic evaluated |
Process score | Rank | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| General growth properties |
Viral growth in cell substrate |
Process resistance |
|||||||||
| Growth speed and titres | Cell-free transmission | Isolation (eggs) | Propagation (eggs) | Stability | Inactivation | Splitting | |||||
| -RNA | Paramyxoviridae | Pneumovirus/hRSV | 0.5 | 0.5 | 0.1 | 0.1 | 0.5 | 0.1 | 0.5 | 0.01 | 24 |
| Metapneumovirus | 0.5 | 1 | 0.5 | 0.5 | 0.5 | 0.1 | 0.5 | 0.04 | 22 | ||
| Parainfluenzavirus | 2 | 1 | 2 | 2 | 0.5 | 0.1 | 0.5 | 0.30 | 11 | ||
| Mumps virus | 1 | 1 | 1 | 1 | 0.5 | 0.1 | 0.5 | 0.10 | 18 | ||
| Measles virus | 1 | 1 | 0.5 | 0.5 | 0.5 | 0.1 | 0.5 | 0.05 | 19 | ||
| +RNA | Coronaviridae | HCoV, SARS-CoV | 1 | 1 | 0.5 | 0.5 | 0.5 | 0.1 | 0.5 | 0.05 | 19 |
| Togaviridae | Rubella virus | 1 | 1 | 0.5 | 0.5 | 0.5 | 0.1 | 0.5 | 0.05 | 19 | |
| Picornaviridae | Human enterovirus | 2 | 1 | 0.5 | 0.5 | 1 | 0.3 | 1 | 0.90 | 9 | |
| Rhinovirus | 1 | 1 | 0.5 | 0.5 | 1 | 0.1 | 1 | 0.20 | 14 | ||
| ss RNA(RT) | Retroviridae | Avian retrovirus | 1 | 0.5 | 2 | 2 | 0.5 | 0.3 | 0.5 | 0.45 | 10 |
| Human retrovirus | 1 | 0.5 | 0.1 | 0.1 | 0.5 | 0.3 | 0.5 | 0.02 | 23 | ||
| ds RNA | Reoviridae | Mammalian reovirus | 2 | 1 | 1 | 1 | 1.5 | 0.5 | 1 | 4.50 | 4 |
| Avian reovirus | 2 | 1 | 2 | 2 | 1.5 | 0.5 | 1 | 9.00 | 1 | ||
| Birnaviridae | Avian birnavirus | 2 | 1 | 2 | 2 | 1.5 | 0.5 | 1 | 9.00 | 1 | |
| ss DNA | Parvoviridae | MVM | 1 | 1 | 0.5 | 0.5 | 1.5 | 0.1 | 1 | 0.30 | 11 |
| Circoviridae | Avian circovirus | 1 | 1 | 1 | 1 | 1.5 | 0.3 | 1 | 1.80 | 5 | |
| Porcine circovirus | 0.5 | 0.5 | 0 | 0 | 1.5 | 0.3 | 1 | 0.00 | 24 | ||
| ds DNA | Herpesviridae | Herpes simplex virus | 2 | 1 | 2 | 2 | 0.5 | 0.5 | 0.5 | 1.50 | 6 |
| Varicella zoster virus | 1 | 1 | 0.5 | 0.5 | 0.5 | 0.5 | 0.5 | 0.25 | 13 | ||
| EBV, CMV, HHV-6-8 | 0.5 | 0.5 | 0.5 | 0.5 | 0.5 | 0.5 | 0.5 | 0.13 | 17 | ||
| Adenoviridae | Human adenovirus | 2 | 1 | 0.5 | 0.5 | 1 | 0.5 | 1 | 1.50 | 6 | |
| Polyomaviridae | JC/BK virus, SV40 | 1 | 1 | 0.5 | 0.5 | 1.5 | 0.5 | 1 | 1.50 | 6 | |
| Avian polyomavirus | 2 | 1 | 2 | 2 | 1.5 | 0.5 | 1 | 9.00 | 1 | ||
| Other agents | – | Mycoplasma spp. | 1 | 0.5 | 2 | 2 | 0.5 | 0.1 | 0.5 | 0.15 | 15 |
| – | Chlamydia spp. | 1 | 0.5 | 2 | 2 | 0.5 | 0.1 | 0.5 | 0.15 | 15 | |
CMV, cytomegalovirus; ds, double-stranded; EBV, Epstein–Barr virus; HCoV, human coronavirus; HHV, human herpes virus; hRSV, human respiratory syncytial virus; MVM, minute virus of mice; SARS-CoV, severe acute respiratory syndrome coronavirus; ss, single-stranded; SV40, simian virus 40.