Table 5.
Process scores for each manufacturing scenario, including human pathogenicity score
| Virus group | Virus family | Type/species | Process score for each manufacturing scenarioa |
Average score for virus | Rank | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| Egg > egg | Egg > MDCK 33016 | Egg > Vero | Egg > Vero > MDCK 33016 | Vero > MDCK 33016 | Normal MDCK > MDCK 33016 | |||||
| -RNA | Paramyxoviridae | Pneumoviruses/hRSV | 0.0 | 0.0 | 0.3 | 0.3 | 0.3 | 0.1 | 0.15 | 25 |
| Metapneumovirus | 0.2 | 0.2 | 0.3 | 0.4 | 0.3 | 0.2 | 0.25 | 22 | ||
| Parainfluenzavirus | 1.5 | 1.5 | 1.5 | 2.3 | 1.5 | 1.5 | 1.63 | 10 | ||
| Mumps virus | 0.5 | 0.5 | 0.8 | 1.0 | 0.8 | 0.5 | 0.67 | 14 | ||
| Measles virus | 0.3 | 0.4 | 0.4 | 0.6 | 0.5 | 0.5 | 0.44 | 17 | ||
| +RNA | Coronaviridae | HCoV, SARS-CoV | 0.5 | 0.3 | 1.3 | 1.3 | 1.1 | 0.3 | 0.78 | 13 |
| Togaviridae | Rubella virus | 0.3 | 0.3 | 0.6 | 0.8 | 0.6 | 0.3 | 0.46 | 16 | |
| Picornaviridae | Human enteroviruses | 4.5 | 2.7 | 11.3 | 11.7 | 9.5 | 5.0 | 7.43 | 7 | |
| Rhinovirus | 1.0 | 0.6 | 2.5 | 2.6 | 2.1 | 0.6 | 1.57 | 12 | ||
| ss RNA (RT) | Retroviridae | Avian retroviruses | 0.5 | 0.2 | 0.2 | 0.2 | – | – | 0.29 | 20 |
| Human retroviruses | 0.2 | 0.2 | 0.2 | 0.3 | 0.2 | 0.2 | 0.24 | 23 | ||
| ds RNA | Reoviridae | Mammalian reovirus | 22.5 | 22.5 | 33.8 | 45.0 | 33.8 | 33.8 | 31.88 | 1 |
| Avian reovirus | 9.0 | 6.8 | 9.0 | 11.3 | – | – | 9.00 | 4 | ||
| Birnaviridae | Avian birnavirus | 9.0 | 4.7 | 9.0 | 9.2 | – | – | 7.99 | 6 | |
| ss DNA | Parvoviridae | MVM | 0.3 | 0.2 | 0.3 | 0.3 | 0.2 | 0.1 | 0.23 | 24 |
| Circoviridae | Avian circovirus | 1.8 | 1.4 | 1.4 | 1.8 | – | – | 1.58 | 11 | |
| Porcine circovirus | 0.0 | 0.0 | 0.5 | 0.5 | 0.5 | 0.1 | 0.26 | 21 | ||
| ds DNA | Herpesviridae | Herpes simplex virus | 7.5 | 7.5 | 7.5 | 11.3 | 7.5 | 7.5 | 8.13 | 5 |
| Varicella zoster virus | 1.3 | 1.3 | 3.1 | 3.8 | 3.1 | 1.3 | 2.29 | 9 | ||
| EBV, CMV, HHV-6-8 | 0.6 | 0.4 | 0.6 | 0.7 | 0.4 | 0.4 | 0.51 | 15 | ||
| Adenoviridae | Human adenovirus | 7.5 | 4.5 | 18.8 | 19.5 | 15.8 | 8.3 | 12.38 | 2 | |
| Polyomaviridae | JC/BK virus, SV40 | 7.5 | 4.5 | 18.8 | 19.5 | 15.8 | 4.5 | 11.75 | 3 | |
| Avian polyomavirus | 9.0 | 4.7 | 5.6 | 5.9 | – | – | 6.30 | 8 | ||
| Other agents | – | Mycoplasma spp. | 0.8 | 0.4 | 0.5 | 0.5 | 0.1 | 0.1 | 0.39 | 19 |
| – | Chlamydia spp. | 0.8 | 0.4 | 0.6 | 0.6 | 0.2 | 0.0 | 0.42 | 18 | |
| Summed process scores for each scenario | 87 | 66 | 129 | 151 | 94 | 65 | – | – | ||
CMV, cytomegalovirus; ds, double-stranded; EBV, Epstein–Barr virus; HCoV, human coronavirus; HHV, human herpes virus; hRSV, human respiratory syncytial virus; MDCK, Madin–Darby canine kidney; MVM, minute virus of mice; SARS-CoV, severe acute respiratory syndrome coronavirus; ss, single-stranded; SV40, simian virus 40.
a
Process scores have been rounded to one decimal place.