Table 2.
Analysis of distribution of combined ICAM3/CD209 genotypes against standardized LDH levels in combined genotype analysis and logistic regression analysis adjusted for age and gender
| ICAM3 +443A>G (Asp143Gly) | CD209 −336A>G | Lower LDH levela | Higher LDH levelb | p Valuec | OR (95% CI) |
|---|---|---|---|---|---|
| Combined genotype | Total = 582 | Total = 95 | 0.024d | ||
| AA | AA | 377 (64.8%) | 62 (65.3%) | — | Reference |
| AA | AG | 89 (15.3%) | 6 (6.3%) | 0.039 | 0.41 (0.17–0.98) |
| AA | GG | 3 (0.5%) | 0 (0%) | 1.00 | — |
| AG | AA | 90 (15.4%) | 20 (21.0%) | 0.286 | 1.35 (0.78–2.35) |
| AG | AG | 15 (2.6%) | 2 (2.1%) | 1.00 | — |
| GG | AA | 7 (1.2%) | 5 (5.3%) | 0.021 | 4.34 (1.34–14.12) |
| GG | AG | 1 (0.2%) | 0 (0%) | 1.00 | — |
| Logistic regression analysis | |||||
| CD209 −336A>G (genotypes) | 0.048 | 0.36 (0.13–0.99) | |||
| ICAM3 +443A>G (genotypes) | 0.004 | 1.97 (1.24–3.11) | |||
| Interaction of CD209 −336A>G and ICAM3 +443A>G | 0.845 | 1.18 (0.22–6.41) |
CI, confidence interval; OR, odds ratio. Note: Only 677 cases were analyzed, as this was the number of cases (with the availability of LDH data) genotyped previously for ICAM3 +443A>G [27].
Boldface values indicate significant results (p < 0.05).
a
Lower LDH levels: standardized LDH levels on admission that were less than the cutoff value of 1.6.
b
Higher LDH levels: standardized LDH levels on admission that were more than the cutoff.
c
χ2 Test, df = 1, unless otherwise indicated.
d
p Value for overall analysis of combined genotype.