Table 3.
Antiviral activity of compounds 1a–c, 2a–cAc, and 3cAc.
| 2-ONN derivative | HCV EC50a | HBV EC50a | HSV-1 |
HSV-2 |
SARS-CoV |
WNV EC50a | |||
|---|---|---|---|---|---|---|---|---|---|
| EC50a | SI | EC50a | SI | EC50a | SI | ||||
| 1a | >100 | >100 | >300 | 1 | >300 | 1 | >0.32 | ND | >2.2 |
| 1b | >100 | >100 | >300 | 1 | >300 | 1 | >26 | ND | >2.2 |
| 1c | >100 | >100 | >12 | <4.7 | >12 | <4.8 | >100 | ND | >4.6 |
| 2aAc | >100 | >100 | >300 | 1 | >300 | 1 | 8.3 | 4.3 | >5.1 |
| 2bAc | >100 | >100 | 67.2 | >4.4 | 60.3 | >4.9 | >100 | ND | >4.7 |
| 2cAc | >100 | >100 | >60 | <4 | >60 | <4 | >32 | ND | >3 |
| 3cAc | >100 | >100 | >60 | <2.4 | >60 | <2.4 | 10 | 1.9 | >3.6 |
| HIA | 2 | – | – | – | – | – | – | – | – |
| 2′C-MC | 1.6 | – | – | – | – | – | – | – | – |
| Lamivudine | – | 0.035 | – | – | – | – | – | – | – |
| Acyclovir | – | – | 3.3 | >30.3 | 9.6 | >10.4 | – | – | – |
| M128533 | – | – | – | – | – | – | 0.59 | >170 | – |
| Infergen | – | – | – | – | – | – | – | – | 0.00004 |
a
EC50 is measured in μM.