Table 4.
Anti influaza activity of 1a–c, 2a–cAc, and 3cAc.
| 2-ONN derivative | Type-B |
Type-A |
||||||
|---|---|---|---|---|---|---|---|---|
| H3N2 |
H5N1 |
H1N1 |
||||||
| EC50a | SI | EC50a | SI | EC50a | SI | EC50a | SI | |
| 1a | >36 | ND | >2.6 | 0 | >100 | >0 | 26 | >3.8 |
| 1b | 46 | >2.2 | 22 | >4.5 | 32 | >3.1 | ND | – |
| 1c | >100 | ND | 16 | >4.2 | >100 | >0 | 32 | >3.1 |
| 2aAc | >3.2 | ND | 24 | >4.2 | 3.2 | 1.3 | ND | – |
| 2bAc | 40 | >2.2 | 33 | >3 | 32 | 1 | ND | – |
| 2cAc | 32 | 1 | 40 | >2.5 | >100 | >0 | ND | – |
| 3cAc | >12 | ND | >32 | ND | >19 | ND | >28 | ND |
| Ribavirin | 2.4 | >130 | 2 | >160 | 4.2 | >76 | 10 | >32 |
EC50 is measured in μM.