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Screening of NSC30049 (7a) analogs for their toxicity with HCT116 cells.
| Compounds | IC50 (μM)a |
|---|---|
| 7a | 2.46 ± 0.14 |
| 7b | 5.75 ± 0.09 |
| 7c | ND |
| 7d | 18.39 ± 2.79 |
| 7e | ND |
| 7f | ND |
| 7h | ND |
| 7g | ND |
| 11a | 18.53 ± 1.41 |
| 11b | 13.10 ± 0.16 |
| 11c | ND |
The IC50 of different analogs was determined by MTT-cell survival assay. Data is the mean ± SE of four estimations. ND, not detectable.
