Table 1.
The novel unsymmetrical aromatic disulfide compounds and their SARS-CoV Mpro inhibitory activities (IC50).
| Entry no. | Chemical structure | IC50 (μM) | Entry no. | Chemical structure | IC50(μM) |
|---|---|---|---|---|---|
| 3-1 |  |
1.871 ± 0.071 | 3-21 |  |
1.250 ± 0.023 |
| 3-2 |  |
2.803 ± 0.052 | 3-22 |  |
2.211 ± 0.152 |
| 3-3 |  |
3.675 ± 0.193 | 3-23 |  |
3.321 ± 0.068 |
| 3-4 |  |
3.130 ± 0.052 | 3-24 |  |
2.555 ± 0.270 |
| 3-5 |  |
1.506 ± 0.184 | 3-25 |  |
2.452 ± 0.126 |
| 3-6 |  |
4.344 ± 0.538 | 3-26 |  |
1.679 ± 0.042 |
| 3-7 |  |
4.100 ± 0.832 | 3-27 |  |
1.557 ± 0.116 |
| 3-8 |  |
1.762 ± 0.044 | 3-28 |  |
1.713 ± 0.052 |
| 3-9 |  |
5.654 ± 0.259 | 3-29 |  |
1.118 ± 0.132 |
| 3-10 |  |
4.511 ± 0.105 | 3-30 |  |
1.264 ± 0.033 |
| 3-11 |  |
5.794 ± 0.050 | 3-31 |  |
0.516 ± 0.060 |
| 3-12 |  |
2.626 ± 0.082 | 3-32 |  |
0.921 ± 0.060 |
| 3-13 |  |
1.651 ± 0.048 | 3-33 |  |
1.437 ± 0.053 |
| 3-14 |  |
2.075 ± 0.016 | 3-34 |  |
1.121 ± 0.060 |
| 3-15 |  |
5.954 ± 0.363 | 3-35 |  |
1.991 ± 0.086 |
| 3-16 |  |
3.957 ± 0.190 | 3-36 |  |
1.495 ± 0.055 |
| 3-17 |  |
4.126 ± 0.094 | 3-37 |  |
0.883 ± 0.028 |
| 3-18 |  |
2.565 ± 0.075 | 3-38 |  |
0.684 ± 0.012 |
| 3-19 |  |
1.947 ± 0.508 | 3-39 |  |
0.697 ± 0.053 |
| 3-20 |  |
2.029 ± 0.488 | 3-40 |  |
1.522 ± 0.214 |