Table 1.
Allelic distribution of selected DC-SIGN polymorphisms in study populations.
| Selected SNPs |
Population allelic frequencies (%) |
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Polymorphism name DCSIGN | Position on cDNA | Nucleotide change | Amino acid change | Rare allele | Zimbabwean (n = 200) | Sub-Saharan African (n = 82) | South African coloured (n = 1422) | Caucasian Canadian (n = 200) | Caucasian European (n = 86) | Thai (n= 80) | Asian (n = 86) | pa |
| p-939 | Promoter | G/A | A | 26.5 | 45.1 | 29.8 | 51.5 | 54.7 | 26.6 | 29.1 | <0.001 | |
| p-871 | Promoter | A/G | G | 5.0 | – | 11.6 | 42.0 | 38.4 | 21.2 | 20.9 | <0.001 | |
| p-745 | Promoter | G/T | T | 5.5 | – | – | 0.0 | – | 0.0 | – | <0.001 | |
| p-336 | Promoter | A/G | G | 45.0 | 37.8 | 42.8 | 18.0 | 20.9 | 8.0 | 5.8 | <0.001 | |
| p-201 | Promoter | G/T | T | 11.5 | – | – | 0.0 | – | 0.0 | – | <0.001 | |
| p-139 | Promoter | A/G | G | 74.0 | 87.8 | 72.1 | 69.5 | 75.6 | 26.7 | 33.7 | ns | |
| Ex4RPT | Exon 4 | 7,5/6,5 | del Y124-I146 | 6.5 | 1.5 | – | – | 2.0 | – | 0.6 | – | ns |
| Ex4+415 | Exon 4 | C/T | R198Q | T | 11.5 | ∼15.0 | – | 0.0 | – | 0.0 | – | <0.001 |
| Ex4+465 | Exon 4 | C/G | E214D | G | 16.0 | ∼15.0 | – | 0.0 | – | 0.0 | – | <0.001 |
| Ex4+485 | Exon 4 | C/T | R221Q | T | 16.0 | ∼15.0 | – | 0.0 | – | 0.0 | – | <0.001 |
| Ex4+547 | Exon 4 | G/C | L242V | C | 7.5 | 6.0 | – | 0.0 | – | 0.0 | – | <0.001 |
| Reference citation | [17] | [20] | [17] | [19] | [17] | |||||||
Amino residues are indicated by single-letter codes at each codon position defined by three-digit numbers.
Abbreviations: DC-SIGN = dendritic cell–specific intracellular adhesion molecule–3–grabbing nonintegrin; n = number of alleles; ns= not significant; SNPs =single nucleotide polymorphisms; – = not determined.
a
Difference between Zimbabweans and Canadians determined by Chi-square test.