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Detailed information about each vaccination protocol.
| Group | Prime (1st vaccination) | 1st Boost (2nd vaccination) | 2nd Boost (3rd vaccination) | Abbreviation |
|---|---|---|---|---|
| PBS | PBS | PBS | PBS | Control groups |
| Ad5/GFP | Ad/GFP | Ad/GFP | Ad/GFP | |
| Spike protein | Spike protein | Spike protein | Spike protein | Homologous prime–boost groups |
| Ad5/MERS | Ad5/MERS | Ad5/MERS | Ad5/MERS | |
| Ad5/MERS–spike protein | Ad5/MERS | Spike protein | Spike protein | Heterologous prime–boost groups |
| Spike protein–Ad5/MERS | Spike protein | Ad5/MERS | Ad5/MERS |
