Table 2.
Cytotoxicity and antiviral activity of Xanthatin in Vero cell cultures.
| Compound | Minimum cytotoxic concentrationa (μM) | EC50b (μM) |
||||
|---|---|---|---|---|---|---|
| Para- influenza-3 virus | Reovirus-1 | Sindbis virus | Coxsackie virus B4 | Punta toro virus | ||
| Xanthatin | ≥20 | >20 | >20 | >20 | >20 | >20 |
| DS-5000 (μg/mL) | >100 | >100 | >100 | 100 | 20 ± 2.3 | 73 ± 3.3 |
| (S)-DHPA | >250 | >250 | >250 | >250 | >250 | >250 |
| Ribavirin | >250 | 112 | >250 | >250 | >250 | 146 ± 7.8 |
a
Required to cause a microscopically detectable alteration of normal cell morphology.
b
Required to reduce virus-induced cytopathogenicity by 50%.