Table 1. Antidepressive-like effects of harmine in animal models.

Reference	Model	Animal	Results	Dose
Farzin & Mansouri24	FST	Mouse	Reduced immobility	5-15 mg/kg (acute)
Fortunato25	FST	Rat	Reduced immobility, increased climbing and swimming, increased BDNF levels in the hippocampus	10-15 mg/kg (acute)
Fortunato26	FST	Rat	Reduced immobility, increased climbing and swimming, increased BDNF levels in the hippocampus	5-15 mg/kg/day (14 days)
Fortunato27	CMS	Rat	Reversed anhedonia, reduced adrenal gland weight, normalized ACTH and BDNF levels	15 mg/kg/day (7 days)
Réus28	Acute and chronic treatment	Rat	Reduced lipid/protein oxidation and increased superoxide dismutase/catalase activity in prefrontal cortex and hippocampus	5-15 mg/kg (acute)5-15 mg/kg/day (14 days)
Réus29	Acute and chronic treatment	Rat	Increased creatine kinase and complex I/IV activity in the prefrontal cortex and striatum	5-15 mg/kg (acute)5-15 mg/kg/day (14 days)
Abelaira30	CMS	Rat	Reversed sucrose intake and prefrontal cortex citrate synthase activity	15 mg/kg/day (7 days)

ACTH = adrenocorticotropic hormone; BDNF = brain-derived neurotrophic factor; CMS = chronic mild stress; FST = forced swim test.