Table 1. Antidepressive-like effects of harmine in animal models.
Reference | Model | Animal | Results | Dose |
---|---|---|---|---|
Farzin & Mansouri24 | FST | Mouse | Reduced immobility | 5-15 mg/kg (acute) |
Fortunato25 | FST | Rat | Reduced immobility, increased climbing and swimming, increased BDNF levels in the hippocampus | 10-15 mg/kg (acute) |
Fortunato26 | FST | Rat | Reduced immobility, increased climbing and swimming, increased BDNF levels in the hippocampus | 5-15 mg/kg/day (14 days) |
Fortunato27 | CMS | Rat | Reversed anhedonia, reduced adrenal gland weight, normalized ACTH and BDNF levels | 15 mg/kg/day (7 days) |
Réus28 | Acute and chronic treatment | Rat | Reduced lipid/protein oxidation and increased superoxide dismutase/catalase activity in prefrontal cortex and hippocampus | 5-15 mg/kg (acute)5-15 mg/kg/day (14 days) |
Réus29 | Acute and chronic treatment | Rat | Increased creatine kinase and complex I/IV activity in the prefrontal cortex and striatum | 5-15 mg/kg (acute)5-15 mg/kg/day (14 days) |
Abelaira30 | CMS | Rat | Reversed sucrose intake and prefrontal cortex citrate synthase activity | 15 mg/kg/day (7 days) |
ACTH = adrenocorticotropic hormone; BDNF = brain-derived neurotrophic factor; CMS = chronic mild stress; FST = forced swim test.