Table 1. Sociodemographic characteristics, utility measures, and transition probabilities for children and adolescents in the base-case analysis.
| Children (n=62)* | Adolescents (n=28)† | |
|---|---|---|
| Age, mean ± standard deviation | 8.62±1.7 | 13.67±1.61 |
| Intelligence quotient, mean ± standard deviation | 96.46±11.8 | 92.5±10.2 |
| Male | 46 (74.2) | 25 (89.3) |
| Ethnicity | ||
| White | 44 (71) | 21 (80.8) |
| Stimulant-naïve | 45 (72.6) | 16 (59.3) |
| ADHD subtype | ||
| Combined | 43 (69.4) | 13 (46.4) |
| Inattentive | 13 (21) | 10 (35.7) |
| Hyperactivity/impulsivity | 3 (4.8) | 1 (3.6) |
| Subthreshold | 3 (4.8) | 4 (14.3) |
| Comorbidity | ||
| Oppositional defiant disorder | 25 (40.3) | 14 (50.0) |
| Conduct disorder | 3 (4.8) | 3 (10.7) |
| Anxiety disorder | 5 (8.1) | 5 (17.9) |
| Mood disorder | 1 (1.6) | 1 (3.6) |
| Transition probabilities | ||
| MPH-IR initiation | 1.0 | 1.0 |
| MPH-IR use, 4th week | 0.7769 | 0.7697 |
| MPH-IR success, 4th week | 0.8941 | 0.9422 |
| MPH-IR, probability of AE in non-success patients/24th week | 0.406‡ | 0.321§ |
| MPH-IR, probability of AE in success patients/24th week | 0.333‡ | 0.091§ |
| Spontaneous improvement, 24th week | 0.09 | 0.09 |
| Utility measures | ||
| Baseline utility | 0.69 | 0.66 |
| Utility gained with MPH-IR | 0.10 | 0.09 |
| Utility gained for spontaneous improvement | 0.04 | 0.04 |
| Disutility for AE | ‐0.04 | ‐0.04 |
| Costs per month, I$ (range) | ||
| MPH-IR (WHO) | 37.8 (0.00-150.00) | |
| One consultation | 5.37 (10.00-25.00) | |
| Natural course | 7.93 (0.00-150.00) | |
| Discount per month | 0.004265319 | |
Data presented as n (%), unless stated otherwise.
ADHD = attention deficit hyperactivity disorder; AE = adverse event; MPH-IR = methylphenidate immediate release; WHO = World Health Organization.
All costs were converted to I$. The 2013 conversion factor is R$ 1.86. For more information, please visit The World Bank website (http://www.worldbank.org/).
*
62 children are the sum of 50 (baseline) plus 12 from ProDAH data set; † 28 adolescents are the sum of 23 (baseline) plus 5 from ProDAH data set; ‡ number of children in the 24th week: 37; § number of adolescents in the 24th week: 19.