Table 1.

Inhibition of integrase activities (3′-processing and strand transfer) of dihydropyrimidine α,γ-diketobutanoic acid derivatives.

Compound No.	IC50 (μM) ± S.D.
	3′- processing Strand transfer (ST)
46	16.9 ± 3.4	0.19 ± 0.12
47	17.4 ± 2.1	1.3 ± 0.1
48	19.1 ± 4.0	0.64 ± 0.16
49	35 ± 8	1.1 ± 0.4
50	72 ± 4.5	5.6 ± 4.6
51	16.3 ± 3.5	1.3 ± 0.5
52	16.6 ± 2.4	1.3 ± 0.5
53	22.5 ± 2.0	0.85 ± 0.12
54	21.1 ± 1.2	2.23 ± 0.27
55	29.3 ± 3.5	0.92 ± 0.14
56	30.7 ± 2.7	2.27 ± 0.28
57	22 ± 4	2.8 ± 0.9