Table 4.
Antibacterial activity data (MIC (in μg/mL) values) of 1-aryl-4-methyl-3,6-bis-(5-methylisoxazol-3-yl)-2-thioxo-2,3,6,10b-tetrahydro-1H-pyrimido [5,4-c]quinolin-5-ones.
| Compound No. | Gram positive |
Gram negative |
||||
|---|---|---|---|---|---|---|
| B. subtilis | B. sphaericus | S. aureus | P. aeruginosa | K. aerogenes | C.violaceum | |
| 76 | 19 | 15 | 15 | 20 | 13 | 18 |
| 77 | 16 | 11 | 10 | 10 | 08 | 06 |
| 78 | 20 | 15 | 10 | 15 | 14 | 18 |
| 79 | 06 | 08 | 09 | 09 | 07 | 05 |
| 80 | 22 | 18 | 25 | 20 | 15 | 18 |
| 81 | 16 | 15 | 15 | 20 | 15 | 16 |
| 82 | 18 | 18 | 12 | 08 | 13 | 11 |
| 83 | 08 | 10 | 09 | 05 | 08 | 06 |
| Ciprofloxacin | 20 | 20 | 25 | 30 | 25 | 25 |
Negative control (acetone)-no activity. Values are indicated in lg/mL.