Table 5.
In vitro macrofilaricidal activity of 2-sulfanyl-6-methyl-1,4-dihydropyrimidines against Brugia malayi.
| Compound No. | Concentration (μM) |
Motilitya | Percent inhibition in MTT reduction over control (means ± SD) |
|---|---|---|---|
| 97 | 100 | 0 | 18.97 ± 1.77 |
| 98 | 100 | 0 | 49.0 ± 11.50 |
| 50 | 0 | NI | |
| 99 | 100 | 0 | 43.14 ± 5.11 |
| 100 | 100 | 0 | 25.74 ± 3.44 |
| 101 | 100 | 0 | 52.11 ± 26.92 |
| 50 | 0 | 19.29 ± 9.49 | |
| 102 | 100 | 0 | 68.61 ± 5.13 |
| 50 | 0 | 68.4692 | |
| 103 | 100 | 0 | NI |
| DEC (citrate) | 100 | 3 | NI |
| 50 | 3 | NI |
Motility is expressed as highly motile (3), low (2), sluggish (1, irreversible) and dead (0); NI = no inhibition.