Table 7.
Antihypertensive activity data shown by compounds at 10 mg/kg dose.
| Compound No. | Average systolic blood pressure (mmHg) at time (min) |
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 0 | 15 | 30 | 60 | 120 | 180 | 240 | 300 | 360 | 600 | 720 | 900 | |
| 108 | 193 ± 3 | 189 ± 2 | 183 ± 1 | 174 ± 2 | 161 ± 2 | 155 ± 1 | 145 ± 2 | 136 ± 1 | 130 ± 2 | 145 ± 1 | 156 ± 3 | 168 ± 4 |
| 109 | 194 ± 1 | 189 ± 1 | 183 ± 2 | 172 ± 1 | 163 ± 3 | 151 ± 2 | 139 ± 1 | 124 ± 2 | 120 ± 3 | 147 ± 2 | 154 ± 4 | 163 ± 2 |
| 110 | 193 ± 3 | 188 ± 1 | 182 ± 2 | 178 ± 1 | 169 ± 2 | 161 ± 3 | 152 ± 3 | 144 ± 2 | 129 ± 3 | 148 ± 2 | 157 ± 1 | 165 ± 2 |
| 111 | 194 ± 2 | 190 ± 1 | 186 ± 2 | 180 ± 1 | 174 ± 2 | 162 ± 1 | 154 ± 2 | 145 ± 1 | 131 ± 2 | 142 ± 1 | 160 ± 2 | 166 ± 3 |
| 112 | 195 ± 1 | 191 ± 2 | 188 ± 3 | 182 ± 3 | 170 ± 1 | 165 ± 2 | 156 ± 2 | 148 ± 1 | 130 ± 3 | 144 ± 1 | 164 ± 2 | 171 ± 2 |
| Nifedipine | 195 ± 3 | 192 ± 1 | 188 ± 2 | 180 ± 1 | 172 ± 1 | 160 ± 2 | 145 ± 1 | 132 ± 3 | 120 ± 2 | 148 ± 1 | 158 ± 2 | 162 ± 1 |