Table 2.

In vitro antitumor activities of compounds 2a-2v.

Compd.	R2	IC50(μΜ)
		K562	HepG2
CPT		0.07 ± 0.01	0.37 ± 0.06
1i	H	6.92 ± 0.28	0.96 ± 0.32
2a	CH3	4.98 ± 0.92	6.67 ± 2.82
2b	CH2CH3	2.20 ± 0.36	4.47 ± 0.23
2c	CH2CH=CH2	0.39 ± 0.05	7.09 ± 1.04
2d	CH2C6H5	0.57 ± 0.11	1.36 ± 0.51
2e	C6H4-4-OCH3	>10	>10
2f	CH2-4-C6H4F	0.56 ± 0.08	1.12 ± 0.33
2g	CH2-3,4-C6H3Cl2	0.43 ± 0.15	0.99 ± 0.02
2h	CH2-4-C6H4Cl	0.35 ± 0.13	0.25 ± 0.09
2i	CH2-3-C6H4Cl	0.20 ± 0.12	0.32 ± 0.12
2j	CH2-2-C6H4Cl	0.38 ± 0.20	0.60 ± 0.24
2k	CH2-4-C6H4Br	0.10 ± 0.15	0.70 ± 0.03
2l	CH2-4-C6H4CH3	0.27 ± 0.03	0.33 ± 0.03
2m	CH2-4-C6H4OCH3	0.03 ± 0.01	0.05 ± 0.03
2n	CH2-3-C6H4OCH3	0.68 ± 0.27	0.70 ± 0.18
2o	CH2-2-C6H4OCH3	0.04 ± 0.01	0.13 ± 0.02
2p	CH2-3,4-C6H3(CH3)2	0.14 ± 0.03	0.41 ± 0.03
2q	CH2-3,4C6H3(OCH3)2	0.06 ± 0.01	1.35 ± 1.86
2r	CH2-4-C6H4CN	0.38 ± 0.07	1.00 ± 0.29
2s	CH2-4-C6H4CF3	0.27 ± 0.03	0.38 ± 0.02
2t	CH2CH2OC6H5	0.40 ± 0.06	0.70 ± 0.25
2u	CH2-2-naphthyl	0.40 ± 0.04	0.38 ± 0.05
2v	CH2-2-piperonyl	0.03 ± 0.01	0.44 ± 0.19