Fig. 5.

Cardiac function was detected by echocardiography using a 2-dimensional guided M-mode ultrasound system in each group by 3LD₅₀ CVB3 challenge 7 days after infection. (A) Representative M-mode echocardiograms for each group (B) VSV-VP1 immunization significantly improved the cardiac systolic function against CVB3 induced myocarditis as evidenced by reduced left ventricular fraction shortening and ejection fraction from echocardiographic data. Values were presented as mean ± SD; n = 6 for each group; ^**P < 0.01. (C) The survival rate of mice was observed for 14 days following 5LD₅₀ infection. Individual experiment was conducted three times with 12 mice per group and one representative data was shown.