Table 3.
Drug susceptibilities of WT HIV-1 RT from subtype B for S-PMEApp 5, S-PMPApp 6, and reference compounds PMEApp 5a and PMPApp 6a.
IC50 (μM)a S-PMEApp 5 |
IC50 (μM)a PMEApp 5a |
IC50 (μM)a S-PMPApp 6 |
IC50 (μM)a PMPApp 6a |
|
---|---|---|---|---|
WT RT | 6.8 ± 2.3 | 7.0 ± 2.7 | 13.9 ± 5.4 | 11.3 ± 3.8 |
IC50 values were determined with recombinant RT assayed on activated calf thymus DNA and averaged (±S.D.) for at least three independent experiments.