Table 4.
Anti-HBV activities and cytotoxicity in HepAD38 and Huh7 cell cultures of S-PMEA 3 and S-PMPA 4 and reference compounds PMEA and PMPA.
| Compound | EC50 (μM)a HepAD38 cells |
EC50 (μM)a Huh7 cells |
CC50 (μM)b |
|---|---|---|---|
| S-PMEA 3 | 3.0 ± 0.1 | 4.5 ± 0.5 | > 150 |
| PMEA | 7.6 ± 0.0 | 6.0 ± 1.0 | > 150 |
| S-PMPA 4 | 2.8 ± 0.7 | 4.0 ± 0.0 | > 150 |
| PMPA | 2.3 ± 0.2 | 4.2 ± 0.3 | > 150 |
a
EC50: effective concentration of compounds inducing a 50% reduction of the level of HBV viral DNA in the culture.
b
CC50: cytotoxic concentration of compounds inducing a 50% reduction of the cell density.