Table 5.
Antiviral activities and cytotoxicity of S-PMEA 3 and S-PMPA 4 and the reference compounds PMEA and PMPA against several DNA viruses in cell culture.
| Compound | EC50 (μM)a |
Minimum cytotoxic concentration (μM)b | |||
|---|---|---|---|---|---|
| Herpes simplex virus-1 (KOS) | Herpes simplex virus-1 (TK− KOS ACVr) | Herpes simplex virus-2 (G) | Vaccinia virus | ||
| S-PMEA 3 | 40 ± 0 | 24 ± 2 | 24 ± 1 | 84 ± 6 | >200 |
| PMEA | 89 ± 6 | 20 ± 4 | 20 ± 3 | >200 | >200 |
| S-PMPA 4 | 169 ± 13 | 80 ± 5 | 48 ± 0 | 80 ± 7 | >200 |
| PMPA | >200 | >200 | >200 | >200 | >200 |
a
EC50: effective concentration of compounds required to reduce virus-induced cytopathicity by 50%.
b
Minimum concentration required to cause a microscopically detectable alteration of normal cell morphology.