Table 2.

Serum antibody responses after oral immunisation with recombinant L. lactis-pNG3043 carrying covalently bound MSA2-Cov or L. lactis GEM particles containing non-covalently bound MSA-nCov

Immunogen	0	2nd	3rd	3rd IgG
L. lactis MSA2-Cov	−ve	3	4	4
L. lactis MSA2-Cov	−ve	2	4	4
L. lactis GEM MSA2-nCov	−ve	2	4	4
L. lactis GEM MSA2-nCov	−ve	2	4	4

Titres determined by IFA at serial 10-fold dilutions, beginning at 1:10, are expressed as the negative logarithms to the base ten. No detectable reaction at a 1:10 dilution of the serum is shown as −ve; 0, 2nd and 3rd refer to preimmune serum and serum obtained after 2 and 3 immunisations, respectively; 3rd IgG is the IgG antibody titre in the serum after three immunisations, as determined with a rabbit γ chain-specific secondary antibody.