Table 3.
Cytotoxicity and antiviral activity of compounds in Vero cell cultures.
| Compd. | Minimum cytotoxic concentrationa (μg/mL) | EC50b (μg/mL) |
||||
|---|---|---|---|---|---|---|
| Para influenza-3 virus | Reovirus-1 | Sindbis virus | Coxsackie virus B4 | Punta Toro virus | ||
| 2a | 100 | >20 | 10 | 5 | 10 | 3 |
| 2b | 20 | >4 | >4 | >4 | >4 | >4 |
| 2c | 100 | >20 | >20 | >20 | >20 | >20 |
| 2d | 100 | >20 | >20 | >20 | >20 | >20 |
| 2e | 100 | >20 | >20 | >20 | >20 | >20 |
| 2f | 20 | >4 | >4 | >4 | >4 | >4 |
| 2g | 100 | >20 | >20 | >20 | >20 | >20 |
| 2h | 100 | >20 | >20 | >20 | >20 | >20 |
| 2i | >100 | >100 | >100 | >100 | >100 | >100 |
| 2j | 20 | >4 | >4 | >4 | >4 | >4 |
| 2k | 100 | >20 | >20 | >20 | >20 | >20 |
| 2l | 100 | >20 | >20 | >20 | >20 | >20 |
| DS-5000 | >100 | >100 | >100 | 20 | 20 | 20 |
| (S)-DHPA (μM) | >250 | >250 | >250 | >250 | >250 | >250 |
| Ribavirin (μM) | >250 | 146 | >250 | >250 | >250 | 146 |
a
Required to cause a microscopically detectable alteration of normal cell morphology.
b
Required to reduce virus-induced cytopathogenicity by 50%.