Table 4.
Anti-Feline Corona Virus (FIPV) and anti-Feline Herpes Virus activity and cytotoxicity in CRFK cell cultures.
| Compd. | CC50a (μg/mL) | EC50b (μg/mL) |
|
|---|---|---|---|
| Feline Corona Virus (FIPV) | Feline Herpes Virus | ||
| 2a | 11.2 | >4 | >4 |
| 2b | 13.8 | >4 | >4 |
| 2c | 13.7 | >4 | >4 |
| 2d | >100 | >100 | >100 |
| 2e | >100 | >100 | >100 |
| 2f | 3.7 | >0.8 | >0.8 |
| 2g | 59.5 | >20 | >20 |
| 2h | 2.6 | >0.8 | >0.8 |
| 2i | >100 | >100 | >100 |
| 2j | 42.2 | >20 | >20 |
| 2k | 42.7 | >20 | >20 |
| 2l | 14.4 | >4 | >4 |
| HHA | >100 | 2.6 | 1.6 |
| UDA | >100 | 11.7 | 53.1 |
| Ganciclovir (μM) | >100 | >100 | 0.8 |
a
50% Cytotoxic concentration, as determined by measuring the cell viability with the colorimetric formazan-based MTS assay.
b
50% Effective concentration, or concentration producing 50% inhibition of virus-induced cytopathic effect, as determined by measuring the cell viability with the colorimetric formazan-based MTS assay. CRFK cells: Crandell-Rees Feline Kidney cells.