Fig. 3.

Inhibitory effect on cell entry of influenza virus HA- and NA-bearing lentiviral pseudoparticles. The GFP-expressing particles carrying H1-HA and N1-NA (from A/PR/8/34) were transduced into MDCK cells in the presence of compounds (X-axis: concentrations in μM), and GFP expression was quantified after three days incubation. The two test compounds, 1a and 63, were tested in parallel with four control compounds, i.e. SA-19, a lipophilic derivative of aglycoristocetin [16]; chloroquine; and two aniline-based influenza fusion inhibitors, 80 and 81 [26]. Data are the mean ± SEM of four independent experiments.