Table 3.
Thirty drugs obtained by four-point pharmacophore search in NCI 3D database
| Name | NSC number | Formula | Bioactivity documented in HIV/OI therapeutics database (http://www.apps1.niaid.nih.gov/struct_search/an/an_search.htm) |
|---|---|---|---|
| PD-ADI | 218321 | C11H16N4O4 | HIV |
| Coformycin | 277817 | C11H16N4O5 | HIV |
| Zidovudine | 602670 | C10H13N5O4 | HIV, HSV, human cytomegalovirus, vaccinia virus, cowpox virus |
| Vira-A | 404241 | C10H13N5O4 | HIV, HSV, human cytomegalovirus, varicella-zoster virus, vaccinia virus, cowpox virus |
| Angustmycin C | 53104 | C11H15N5O5 | |
| ARA-AMP | 259272 | C10H14N5O7P | HIV, HSV, vaccinia virus |
| Cordycepin | 63984 | C10H13N5O3 | HIV |
| Triciribine | 154020 | C13H16N6O4 | HIV, human cytomegalovirus, HSV |
| 5-AZCR | 102816 | C8H12N4O5 | HIV |
| Puromycin | 3055 | C22H29N7O5 | HIV, M. tuberculosis |
| CHETOMIN | 289491 | C31H30N6O6S4 | HIV |
| Vengicide | 99843 | C12H13N5O4 | Human cytomegalovirus |
| Spongothymidin | 68929 | C10H14N2O6 | HIV, HSV, varicella-zoster virus |
| Arauridine | 68928 | C9H12N2O6 | |
| P-Ara-C | 135962 | C25H43N3O6 | HIV |
| Pyrazofurin | 143095 | C9H13N3O6 | HIV, vaccinia virus, West Nile virus |
| Thymidin | 21548 | C10H14N2O5 | HIV, varicella-zoster virus |
| Radibud | 38297 | C9H11BrN2O5 | |
| Alexan | 63878 | C9H13N3O5 | HIV, HSV, human cytomegalovirus, varicella-zoster virus, measles virus |
| Floxuridin | 27640 | C9H11FN2O5 | HIV, HSV, vaccinia virus |
| Gemcitabine | 613327 | C9H12ClF2N3O4 | HIV, cowpox virus, vaccinia virus |
| Dideoxyguanosine | 619072 | C10H13N5O3 | HIV, HBV |
| 2′,3′-Dideoxycytidine | 606170 | C9H13N3O3 | HIV, HBV |
| 5-Bromo-2′-deoxycytidine | 61765 | C9H12BrN3O4 | HSV |
| Ribavirin | 163039 | C8H12N4O5 | HIV, HSV, HCV, influenza virus, dengue virus, measles virus, respiratory syncytial virus, rhinovirus, polio virus, vaccinia virus, cowpox virus |
| Azauridine | 32074 | C8H11N3O6 | West Nile virus, cowpox virus, vaccinia virus, dengue virus, Japanese encephalitis virus, Yellow fever virus |
| Fialuridine | 678514 | C9H10FIN2O5 | Cowpox virus, vaccinia virus, HSV, varicella-zoster virus |
| Emanil | 39661 | C9H11IN2O5 | HIV, HSV, cowpox virus, vaccinia virus, varicella-zoster virus |
| Tubercidin | 56408 | C11H14N4O4 | HIV, vaccinia virus, human cytomegalovirus |
| Viroptic | 75520 | C10H11F3N2O5 | HSV, cowpox virus, vaccinia virus |