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. 2005 Jan 14;23(17):2269–2272. doi: 10.1016/j.vaccine.2005.01.036

Fig. 3.

Fig. 3

SARS (N) DNA vaccine induces in vivo human CTL against SARS CoV in the SCID-PBL/hu human immune systems. 4 × 107 PBL from healthy human volunteers were administered i.p. into IL-2 receptor γ-chain disrupted NOD SCID mice [IL-2R (−/−) NOD-SCID], and SCID-PBL/hu mice were constructed 50 μg of SARS (N) DNA vaccine or 50 μg of SARS (S) DNA vaccine. 1 × 105 spleen cells from SCID-PBL/hu were cultured with 10 μg of recombinant SARS (N) protein for 72 h. IFN-γ production in the culture supernatant was assayed using ELISA.