Table 3.
The influence of compounds 4d and 4f on the growth of individual tumor cell lines (GI50 < 5 μM).
| Compound | Disease | Cell line | GI50, μM | TGI, μM |
|---|---|---|---|---|
| 4d | Leukemia | CCRF-CEM | 2.85 | 11.3 |
| Leukemia | RPMI-8226 | 2.12 | 6.91 | |
| Leukemia | SR | 2.85 | 9.02 | |
| Leukemia | HL-60(TB) | 3.35 | 9.14 | |
| Leukemia | K-562 | 4.58 | 100.0 | |
| NSC lung cancer | HOP-62 | 4.85 | 19.8 | |
| NSC lung cancer | NCI-H460 | 4.18 | 18.7 | |
| Colon cancer | HCT-116 | 4.56 | 16.4 | |
| Colon cancer | HCT-15 | 4.85 | 24.6 | |
| Colon cancer | KM12 | 4.76 | 15.3 | |
| CNS cancer | SF-295 | 2.99 | 10.0 | |
| CNS cancer | U251 | 4.29 | 16.6 | |
| Melanoma | LOX IMVI | 3.21 | 17.9 | |
| Melanoma | MDA-MB-435 | 3.91 | 31.7 | |
| Melanoma | UACC-62 | 2.83 | 9.28 | |
| Ovarian cancer | OVCAR-3 | 3.17 | 11.0 | |
| Renal cancer | 786-0 | 2.96 | 13.5 | |
| Prostate Cancer | PC-3 | 4.63 | 44.4 | |
| Prostate Cancer | DU-145 | 4.64 | 18.4 | |
| 4f | Leukemia | HL-60(TB) | 3.20 | 6.48 |
| Leukemia | K-562 | 1.90 | 11.2 | |
| Leukemia | MOLT-4 | 1.64 | 7.41 | |
| Leukemia | RPMI-8226 | 1.97 | 5.88 | |
| Leukemia | SR | 1.98 | 5.92 | |
| NSC lung cancer | A549/ATCC | 3.06 | 100.0 | |
| NSC lung cancer | HOP-92 | 1.17 | 9.72 | |
| NSC lung cancer | NCI-H322M | 2.89 | 100.0 | |
| NSC lung cancer | NCI-H460 | 1.89 | 4.70 | |
| Colon cancer | HCT-116 | 3.01 | 13.9 | |
| Colon cancer | HCT-15 | 2.41 | 100.0 | |
| CNS cancer | SF-295 | 2.45 | 9.12 | |
| CNS cancer | SF-539 | 2.43 | 5.79 | |
| CNS cancer | U251 | 2.58 | 13.2 | |
| Melanoma | MDA-MB-435 | 2.70 | 16.5 | |
| Melanoma | SK-MEL-5 | 2.09 | 22.5 | |
| Melanoma | UACC-62 | 2.66 | 12.8 | |
| Ovarian cancer | OVCAR-3 | 2.90 | 10.6 | |
| Renal cancer | A498 | 1.41 | 5.38 | |
| Prostate Cancer | PC-3 | 4.94 | 100.0 | |
| Prostate Cancer | DU-145 | 4.27 | 100.0 | |
| Breast cancer | MCF-7 | 2.53 | 14.1 | |
| Breast cancer | HS 578T | 1.94 | 8.26 | |
| Breast cancer | BT-549 | 2.16 | 7.75 | |
| Breast cancer | T-47D | 1.53 | 9.40 |