Table 5.
Antiviral activity of the synthesized compounds.
| Compound | Virus | Virus strain | EC50a μM | SDb | CC50c μM | SD | SId |
|---|---|---|---|---|---|---|---|
| 1a | Flu A (H1N1) | California/07/2009 | 9.82 | 6.23 | 10.30 | 5.75 | 1.1 |
| Flu A (H3N2) | Perth/16/2009 | 4.31 | 3.35 | 6.23 | 4.55 | 1.4 | |
| Flu A (H5N1) | Duck/MN/1525/81 | 7.90 | 0.45 | 12.46 | 6.95 | 1.6 | |
| Flu B | Florida/4/2006 | 4.55 | 2.63 | 8.38 | 5.75 | 1.8 | |
| SARS CoV | Urbani | >23.47 | 6.95 | 23.47 | 6.95 | 0 | |
| 1b | Flu A (H1N1) | California/07/2009 | 4.27 | 3.08 | 4.50 | 3.32 | 1.0 |
| Flu A (H3N2) | Perth/16/2009 | 2.84 | 0.71 | 3.08 | 0.71 | 1.0 | |
| Flu A (H5N1) | Duck/MN/1525/81 | 5.21 | 2.13 | 6.40 | 2.61 | 1.2 | |
| Flu B | Florida/4/2006 | 3.08 | 1.66 | 4.98 | 2.13 | 1.6 | |
| SARS CoV | Urbani | >23.23 | 6.87 | 23.23 | 6.87 | 0 | |
| 2a | Flu A (H1N1) | California/07/2009 | 141.66 | 40.73 | 219.60 | 90.32 | 1.6 |
| Flu A (H3N2) | Perth/16/2009 | 53.13 | 53.13 | 74.38 | 88.55 | 1.4 | |
| Flu A (H5N1) | Duck/MN/1525/81 | 21.78 | 20.01 | >354.19 | 0 | >16.3 | |
| Flu B | Florida/4/2006 | 79.69 | 70.84 | 170.01 | 141.68 | 2.1 | |
| SARS CoV | Urbani | >313.46 | 70.84 | 313.46 | 70.84 | 0 | |
| 2b | Flu A (H1N1) | California/07/2009 | 54.47 | 24.60 | 73.80 | 22.84 | 1.3 |
| Flu A (H3N2) | Perth/16/2009 | >13.35 | 6.68 | 13.35 | 6.68 | 0 | |
| Flu A (H5N1) | Duck/MN/1525/81 | 50.96 | 33.39 | 56.23 | 28.12 | 1.1 | |
| Flu B | Florida/4/2006 | 35.14 | 36.90 | 42.17 | 35.14 | 1.3 | |
| SARS CoV | Urbani | >351.44 | 0 | >351.44 | 0 | 0 | |
| 2c | Flu A (H1N1) | California/07/2009 | 119.64 | 100.84 | 176.04 | 119.64 | 1.5 |
| Flu A (H3N2) | Perth/16/2009 | 18.80 | 7.52 | 25.64 | 18.80 | 1.3 | |
| Flu A (H5N1) | Duck/MN/1525/81 | 179.46 | 111.09 | 264.92 | 94.00 | 1.5 | |
| Flu B | Florida/4/2006 | 95.71 | 164.08 | 131.60 | 158.95 | 1.4 | |
| SARS CoV | Urbani | >341.83 | 0 | >341.83 | 0 | 0 | |
| 3d | Flu A (H1N1) | California/07/2009 | 13.70 | 16.34 | 14.69 | 15.68 | 1.1 |
| Flu A (H3N2) | Perth/16/2009 | >6.60 | 3.63 | 6.60 | 3.63 | 0 | |
| Flu A (H5N1) | Duck/MN/1525/81 | >24.76 | 24.76 | 24.76 | 24.76 | 0 | |
| Flu B | Florida/4/2006 | 57.78 | 75.94 | 59.43 | 75.94 | 1.0 | |
| SARS CoV | Urbani | 21.46 | 5.78 | 34.67 | 19.81 | 1.6 | |
| 3e | Flu A (H1N1) | California/07/2009 | 4.01 | 1.82 | 4.56 | 2.37 | 1.1 |
| Flu A (H3N2) | Perth/16/2009 | >2.37 | 0.73 | 2.37 | 0.73 | 0 | |
| Flu A (H5N1) | Duck/MN/1525/81 | 4.38 | 2.19 | 6.20 | 4.74 | 1.4 | |
| Flu B | Florida/4/2006 | 4.01 | 4.20 | 8.39 | 10.22 | 2.1 | |
| SARS CoV | Urbani | >16.78 | 3.47 | 16.78 | 3.47 | 0 | |
| Ribavirin | Flu A (H1N1) | California/07/2009 | 23.75 | 2.46 | >348.07 | 122.85 | >15 |
| Flu A (H3N2) | Perth/16/2009 | 18.43 | 11.88 | >368.54 | 69.61 | >20 | |
| Flu A (H5N1) | Duck/MN/1525/81 | 18.43 | 7.37 | >323.50 | 90.09 | >20 | |
| Flu B | Florida/4/2006 | 5.73 | 2.05 | >405.39 | 12.28 | >69 | |
| Oseltamirvir-carboxylate | Flu A (H1N1) | California/07/2009 | 18.99 | 10.90 | >35.17 | 0.0 | >1.9 |
| Flu A (H3N2) | Perth/16/2009 | 3.06 | 2.81 | >35.17 | 0.0 | >11 | |
| Flu A (H5N1) | Duck/MN/1525/81 | 0.11 | 0.007 | >35.17 | 0.0 | >326 | |
| Flu B | Florida/4/2006 | 3.52 | 4.22 | >35.17 | 0.0 | >10 | |
| M128533 Protease inhibitor | SARS CoV | Urbani | 1.56 | 1.18 | >236.41 | 0.0 | >152 |
a
50% Effective (virus-inhibitory) concentration.
b
50% Cytotoxic concentration, determined in uninfected cells.
c
SD – standard deviation.
d
Selectivity index (CC50/EC50), derived from three independent experiments.